Inter are forced to use Ivan Perisic as a striker with Lautaro Martinez, as Romelu Lukaku is out of this Champions League trip to Eden Hazard and Karim Benzema’s Real Madrid.
It kicks off at 20.00 GMT.
You can follow all the build-up and action as it happens from this game and Atalanta-Liverpool on the LIVEBLOG.
Inter are forced to use Ivan Perisic as a striker with Lautaro Martinez, as Romelu Lukaku is out of this Champions League trip to Eden Hazard and Karim Benzema’s Real Madrid.
It kicks off at 20.00 GMT.
This group has not gone according to predictions at all so far, with Real Madrid scraping one point after a 3-2 home defeat to Shakhtar Donetsk and 2-2 draw at Borussia Monchengladbach, having been trailing by multiple goals in both games.
As for the Nerazzurri, they had stalemates with both the Germans and Ukrainians, so they went into this group with Real Madrid on one point, Inter and Gladbach two, Shakhtar Donetsk four.
They have also both been struggling domestically too, and Antonio Conte is forced to do without top scorer Lukaku due to a thigh injury.
Alexis Sanchez isn’t fully fit either, so Perisic is a makeshift striker alongside Lautaro Martinez, having scored a last-gasp equaliser in Saturday’s 2-2 draw with Parma.
Nicolò Barella is chosen as a the trequartista in support rather than misfiring Christian Eriksen, with Arturo Vidal and Marcelo Brozovic flanked by Ashley Young and ex-Real Madrid wing-back Achraf Hakimi.
As for Zinedine Zidane, he lost Eder Militao to a positive COVID-19 test, joining injured Dani Carvajal, Nacho, Alvaro Odriozola and Martin Odegaard.
Lucas Vazquez is again used as a makeshift right-back rather than Marcelo, with Hazard, Marco Asensio and Karim Benzema upfront.
Once again, Real Madrid are opting to play at the Estadio Alfredo Di Stefano rather than the Bernabeu, as it will feel less empty behind closed doors.
Real Madrid: Courtois; Lucas Vazquez, Varane, Ramos, Mendy; Valverde, Casemiro, Kroos; Asensio, Benzema, E Hazard
Real Madrid bench: Lunin, Altube, Modric, Marcelo, Jovic, Vinicius, Isco, Mariano Diaz, Rodrygo, Santos
Inter: Handanovic; D'Ambrosio, De Vrij, Bastoni; Hakimi, Vidal, Brozovic, Young; Barella; Lautaro Martinez, Perisic
Inter bench: Padelli, Stankovic, Gagliardini, Alexis Sanchez, Kolarov, Ranocchia, Eriksen, Darmian, Skriniar, Nainggolan, Pinamonti
Ref: Turpin (FRA)