Winter Champions Juventus rest Cristiano Ronaldo for the trip to Bergamo, while Europe-chasing Atalanta have a reshuffled defence.
It kicks off at the Stadio Azzurri d’Italia at 14.00 GMT.
The Bianconeri have already secured the Winter title with two rounds to spare, sitting eight points clear of Napoli.
Winter Champions Juventus rest Cristiano Ronaldo for the trip to Bergamo, while Europe-chasing Atalanta have a reshuffled defence.
It kicks off at the Stadio Azzurri d’Italia at 14.00 GMT.
The Bianconeri have already secured the Winter title with two rounds to spare, sitting eight points clear of Napoli.
Max Allegri takes the opportunity of this unusual Boxing Day fixture to rest Cristiano Ronaldo for the first time this season, giving Douglas Costa a start with Paulo Dybala and on-form Mario Mandzukic.
Miralem Pjanic is also rested for Emre Can, but Federico Bernardeschi, Juan Cuadrado, Andrea Barzagli, Joao Cancelo and Blaise Matuidi are out.
Atalanta are back in the race for a European spot, but are forced to revamp their defence, as Rafael Toloi and Jose Luis Palomino are suspended following their red cards in the defeat to Genoa.
Marten De Roon is injured, with Ali Adnan on international duty.
Papu Gomez and Josip Ilicic provide the creativity behind powerhouse centre-forward Mario Mandzukic.
Juve are unbeaten against Atalanta in Serie A since a 2-1 result at the Stadio Azzurri d’Italia in February 2001, followed by 23 victories and four draws. However, the last two trips to Bergamo both ended 2-2.
Atalanta: Berisha; Mancini, Djimsiti, Masiello; Hateboer, Pasalic, Freuler, Castagne; Gomez; Ilicic, Duvan Zapata
Juventus: Szczesny; De Sciglio, Bonucci, Chiellini, Alex Sandro; Khedira, Bentancur, Emre Can; Douglas Costa, Dybala; Mandzukic
Ref: Banti