Papu Gomez is passed fit to start with Josip Ilicic and Duvan Zapata, as Atalanta host Shakhtar Donetsk with some injury worries in the Champions League.
It kicks off at San Siro at 17.55 UK time (16.55 GMT).
You can follow the build-up and action as it happens from this game and Juventus-Bayer Leverkusen on the LIVEBLOG.
Papu Gomez is passed fit to start with Josip Ilicic and Duvan Zapata, as Atalanta host Shakhtar Donetsk with some injury worries in the Champions League.
It kicks off at San Siro at 17.55 UK time (16.55 GMT).
You can follow the build-up and action as it happens from this game and Juventus-Bayer Leverkusen on the LIVEBLOG.
The Orobici had a rude awakening in their historic first ever Champions League match, losing 4-0 away to Dinamo Zagreb, so hope that those initial nerves have now been shaken off.
They won’t exactly have home advantage, because for this season their European fixtures will be played at the Stadio Giuseppe Meazza in Milan, as the Gewiss Stadium isn’t ready yet.
In previous Europa League campaigns, they played at Sassuolo’s Mapei Stadium in Reggio-Emilia, so this is at least much closer to Bergamo.
There were some concerns around Papu Gomez, as the captain was struggling with a slight muscular issue, but he has been passed fit to start with Ilicic and Duvan Zapata.
Luis Muriel is back on the bench after missing several games with tonsillitis, while Simon Kjaer again makes way for Andrea Masiello and Jose Luis Palomino.
Ukraine international Ruslan Malinovskyi is ready to come on as an impact sub.
Shakhtar Donetsk have won all nine games they played in their domestic league this season, scoring 28 goals, but they lost their Champions League opener to Manchester City, 3-0 at home.
It is a different team since Coach Paulo Fonseca left to take over at Roma, replaced by Luis Castro.
Midfielder Andrii Totovystski is out injured, with Davit Khocholava and Bogdan Butko not fully fit in defence.
Taison remained, despite practically begging to be allowed to join Fonseca at Roma this summer, and supports Junior Moraes in attack with Marlos and Viktor Kovalenko rather than benched Yevhen Konoplyanka.
Atalanta: Gollini; Toloi, Masiello, Palomino; Hateboer, De Roon, Pasalic, Castagne; Gomez; Ilicic, Duvan Zapata
Atalanta bench: Sportiello, Kjaer, Gosens, Muriel, Freuler, Malinovskyi, Djimsiti
Shakhtar Donetsk: Pyatov; Bolbat, Kryvtsov, Matviyenko, Ismaily; Stepanenko, Patrick; Marlos, Kovalenko, Taison; Junior Moraes
Shakhtar bench: Shevchenko, Marcos Antonio, Dentinho, Konoplyanka, Solomon, Bondar, Dodo
Ref: Stieler (GER)