Cristiano Ronaldo and Paulo Dybala take on Mauro Icardi and Ivan Perisic in a fascinating Derby d’Italia between Juventus and Inter.
It kicks off at 19.30 GMT at the Allianz Juventus Stadium in Turin.
You can follow all the build-up and action as it happens and give your views on the LIVEBLOG.
Cristiano Ronaldo and Paulo Dybala take on Mauro Icardi and Ivan Perisic in a fascinating Derby d’Italia between Juventus and Inter.
It kicks off at 19.30 GMT at the Allianz Juventus Stadium in Turin.
You can follow all the build-up and action as it happens and give your views on the LIVEBLOG.
The Serie A leaders are hoping to break out further in front of the chasing pack, including third-placed Inter, as they are still unbeaten in the league and dropped points only against Genoa.
Sami Khedira, Alex Sandro and Andrea Barzagli are out of action, but Emre Can is on the bench for the first time since his surgery to remove a thyroid nodule.
Rodrigo Bentancur again takes the midfield reins, although Miralem Pjanic returns from a rest, while Dybala, Mario Mandzukic and Cristiano Ronaldo form the trident attack.
Joao Cancelo faces his former club with Mattia De Sciglio as the full-backs.
Inter need to get back on track after some stuttering results, as they lost in the Champions League to Tottenham Hotspur and could be distracted by the upcoming clash with PSV Eindhoven.
Their European future is out of their hands, as if they can’t get a better result than Spurs away to Barcelona, then they’re out of the tournament.
Radja Nainggolan and Dalbert are still carrying knocks after missing the 2-2 draw with Roma.
Luciano Spalletti makes some adjustments, as Sime Vrsaljko is back from injury to replace Danilo D’Ambrosio, while Joao Miranda is favoured rather than Stefan de Vrij for his physicality.
Roberto Gagliardini is a surprise pick in the middle of the park, sending Matias Vecino to the bench.
Matteo Politano and Perisic flank hitman Icardi in this battle of the potential Capocannoniere winner with Cristiano Ronaldo.
The last time Inter beat Juve was 2-1 at San Siro in September 2016, followed by a draw and two defeats.
The Nerazzurri haven’t conquered the Juventus Stadium since a 3-1 result in November 2012, leaving here with only two stalemates from six visits between Serie A and the Coppa Italia.
Juventus: Szczesny; De Sciglio, Bonucci, Chiellini, Cancelo; Bentancur, Pjanic, Matuidi; Dybala, Mandzukic, Ronaldo
Juventus bench: Perin, Pinsoglio, Benatia, Douglas Costa, Cuadrado, Emre Can, Rugani, Bernardeschi, Spinazzola
Inter: Handanovic; Vrsaljko, Skriniar, Miranda, Asamoah; Gagliardini, Brozovic, Joao Mario; Politano, Icardi, Perisic
Inter bench: Padelli, De Vrij, Vecino, Lautaro Martinez, Keita, Ranocchia, Borja Valero, D’Ambrosio, Candreva
Ref: Irrati