Inter change system again with Eder the lead striker in their Champions League play-off with Roma, who drop Edin Dzeko.
It kicks off at 19.45 GMT, follow all the build-up and action while giving your views on the LIVEBLOG.
Luciano Spalletti’s side have amassed eight consecutive Serie A victories and want to prove the Champions League exit to Real Madrid is behind them.
Inter change system again with Eder the lead striker in their Champions League play-off with Roma, who drop Edin Dzeko.
It kicks off at 19.45 GMT, follow all the build-up and action while giving your views on the LIVEBLOG.
Luciano Spalletti’s side have amassed eight consecutive Serie A victories and want to prove the Champions League exit to Real Madrid is behind them.
Dzeko is dropped in favour of a more rapid trident attack with Diego Perotti as the False 9, Stephan El Shaarawy and Mohamed Salah.
Antonio Rudiger returns from injury to bolster the defence, while Daniele De Rossi is only fit enough for a spot on the bench.
The Rome Derby is up next in Serie A, so with both Miralem Pjanic and Radja Nainggolan one booking away from suspension, that’s another factor to consider.
Inter sit in fourth place and Roberto Mancini is forced to reshuffle again, as Rodrigo Palacio sits out a ban with injured Mauro Icardi and Stevan Jovetic.
Geoffrey Kondogbia has failed a fitness test after a knock against Bologna and isn’t even on the bench, so Jonathan Biabiany is picked.
This moves Marcelo Brozovic into a deeper role in a 4-2-3-1 formation, leaving Eder as the lone available striker.
Ivan Perisic and Adem Ljajic, who is on loan with option to buy from Roma, help support the ex-Sampdoria star.
Inter’s last Serie A victory away to Roma was all the way back in October 2008, but it was a memorable result: 4-0. The Coach at the time was Roberto Mancini. Since then, the Nerazzurri managed three draws from six visits.
Roma: Szczesny; Florenzi, Rüdiger, Manolas, Digne; Pjanic, Keita, Nainggolan; Salah, Perotti, El Shaarawy
Roma bench: De Sanctis, Zukanovic, Emerson, Torosidis, Maicon, De Rossi, Strootman, Vainqueur, Dzeko, Iago Falque, Totti, Ucan
Inter: Handanovic; D’Ambrosio, Miranda, Murillo, Nagatomo; Medel, Brozovic; Biabiany, Ljajic, Perisic; Eder
Inter bench: Carrizo, Berni, Santon, Juan Jesus, Telles, Gnoukouri, Melo, Manaj