Fiorentina welcome Federico Chiesa back and aim for a seventh consecutive victory, but SPAL are unbeaten in six and forced into changes.
It kicks off at the Stadio Franchi at 11.30 UK time (10.30 GMT).
Follow the build-up and action as it happens from all today’s Serie A games on the LIVEBLOG.
The Viola have been unstoppable in recent weeks and the tragic loss of captain Davide Astori has only cemented their team spirit further.
Fiorentina welcome Federico Chiesa back and aim for a seventh consecutive victory, but SPAL are unbeaten in six and forced into changes.
It kicks off at the Stadio Franchi at 11.30 UK time (10.30 GMT).
Follow the build-up and action as it happens from all today’s Serie A games on the LIVEBLOG.
The Viola have been unstoppable in recent weeks and the tragic loss of captain Davide Astori has only cemented their team spirit further.
Player Cristiano Biraghi, members of the staff and even Coach Stefano Pioli got tattoos to remember him by forever with his initials and shirt number: #DA13
Chiesa returns from suspension after missing the win away to Roma, but Milan Badelj is still out injured with Simone Lo Faso.
Giovanni Simeone has found the back of the net in each of his last three games and four would be a new personal career best.
Vincent Laurini is not even on the bench, as his partner is about to give birth imminently and he is on family leave.
SPAL are on strong form too, as they are unbeaten in six rounds – including a draw with leaders Juventus – and need every point they can get to escape relegation in their first top flight campaign for 50 years.
Coach Leonardo Semplici is from Florence and a self-confessed Viola fanatic, but he is forced to reshuffle his pack at the Stadio Franchi.
Jasmin Kurtic, Pasquale Schiattarella, Alberto Grassi, Marco Borriello, Boukary Drame and Stefan Simic are all on the treatment table.
It means Mattia Vitale is given a rare nod in midfield with Sergio Floccari a surprise choice rather than Alberto Paloschi in attack.
Thiago Cionek is able to start in defence despite flu symptoms.
Fiorentina: Sportiello; Milenkovic, Vitor Hugo, Pezzella, Biraghi; Benassi, Veretout, Dabo; Saponara; Chiesa, Simeone
SPAL: Meret; Cionek, Vicari, Felipe; Lazzari, Everton Luiz, Viviani, Vitale, Costa; Antenucci, Floccari
Ref: Orsato