Jose Sosa has stepped in for the suspended Marek Hamsik as second-place Napoli welcome Fiorentina in the early kick-off.
The Partenopei are forced to do without Hamsik due to a ban, so Sosa takes the support role behind Ezequiel Lavezzi and on-form Edinson Cavani.
Fiorentina's injury problems continue to cause problems with Juan Manuel Vargas, Vlada Avramov, Cesare Natali, Alessio Cerci, Stevan Jovetic and Sebastien Frey absent.
Per Kroldrup returns from his ban to complete the defence, but Khouma Babacar is benched in favour of Mario Alberto Santana and Adem Ljajic in a 4-3-3 system.
Napoli: De Sanctis, Grava, Cannavaro, Campagnaro, Maggio, Gargano, Pazienza, Dossena, Sosa, Lavezzi, Cavani
Napoli bench: Iezzo, Aronica, Cribari, Zuniga, Yebda, Vitale, Dumitru
Fiorentina: Boruc, De Silvestri, Gamberini, Kroldrup, Pasqual, Donadel, D'Agostino, Montolivo, Santana, Ljajic, Gilardino
Fiorentina bench: Seculin, Comotto, Camporese, Zanetti, Bolatti, Marchionni, Babacar
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!