Mattia Destro returns to Tuscany to start against his former club, as Roma face on-form Siena with some surprising changes.
Destro was the subject of a bidding war over the summer after scoring 12 Serie A goals for Siena last season.
He is back at the Stadio Artemio Franchi as an opponent now and starts because Erik Lamela, Rodrigo Taddei and Maarten Stekelenburg are injured.
Daniele De Rossi sits out the last of his three-match ban for violent conduct, while Pablo Daniel Osvaldo has a bruised foot and is only fit for the bench.
Unusually, Miralem Pjanic has been picked as the third prong of the trident attack, leaving Nico Lopez on the touchline again, as Panagiotis Tachtsidis returns to the midfield.
Siena are on fine form with eight points from the last four rounds, though they remain in the relegation zone thanks to a six-point penalty.
Goalkeeper Andrea Campagnolo and winger Angelo are on the treatment table, so Gianluca Pegolo wears the gloves.
Francesco Valiani and Alessandro Rosina support centre-forward Emanuele Calaiò.
Marcelo Larrondo is available for the first time this season after his ban in the betting scandal expired.
Siena: Pegolo; Neto, Contini, Felipe; Sestu, Vergassola, Bolzoni, Rubin; Valiani, Rosina; Calaiò
Siena bench: Farelli, Marini, Paci, Del Grosso, Coppola, D'Agostino, Rodriguez, Mannini, Verre, Zé Eduardo, Reginaldo, Larrondo
Roma: Goicoechea; Piris, Marquinhos, Castan, Balzaretti; Bradley, Tachtsidis, Florenzi; Pjanic, Destro, Totti
Roma bench: Lobont, Svedkauskas, Burdisso, Romagnoli, Dodò, Perrotta, Lopez, Osvaldo
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!