Lorenzo Insigne takes on his former club in the lunchtime kick-off, as Pescara visit second placed Napoli.
The Partenopei need a win to keep hold of their position and keep up with Serie A leaders Juventus, who beat Torino last night.
Goran Pandev, Christian Maggio and Salvatore Aronica are out, so Insigne partners the returning Edinson Cavani.
It’s a special game for Insigne, who shot to fame last season when taking Pescara to promotion from Serie B.
Gokhan Inler is used in midfield despite the fact he is a yellow card away from suspension and next week Napoli face Inter.
The Delfini badly need a boost under new Coach Cristiano Bergodi after a dismal start to the campaign.
Defender Antonio Balzano sits out a ban, joining the injured Giuseppe Colucci, Manuele Blasi, Juan Fernando Quintero and Jonathas.
Napoli: De Sanctis; Gamberini, Cannavaro, Britos; Mesto, Behrami, Inler, Hamsik, Zuniga; Insigne, Cavani
Pescara: Perin; Romagnoli, Terlizzi, Bocchetti; Zanon, Bjarnason, Togni, Cascione, Modesto; Weiss; Vukusic
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!