Napoli have Gonzalo Higuain back with Dries Mertens in their showdown for second place, while Roma choose a rapid trident attack.
It kicks off at the Stadio Olimpico at 14.00 UK time (13.00 GMT), follow the build-up and action on our LIVEBLOG.
There is so much at stake in this match and Juventus will be watching with champagne on ice. As they won 2-1 away to Fiorentina last night, they will be crowned champions if Napoli fail to get a victory today.
Napoli have Gonzalo Higuain back with Dries Mertens in their showdown for second place, while Roma choose a rapid trident attack.
It kicks off at the Stadio Olimpico at 14.00 UK time (13.00 GMT), follow the build-up and action on our LIVEBLOG.
There is so much at stake in this match and Juventus will be watching with champagne on ice. As they won 2-1 away to Fiorentina last night, they will be crowned champions if Napoli fail to get a victory today.
The title has sailed, but Maurizio Sarri’s men still have to lock down second place, which is worth automatic Champions League qualification without going through a preliminary round.
Higuain is back after a three-match ban and eager to add to his remarkably tally of 30 goals in 31 Serie A games.
Mertens surprisingly knocks Lorenzo Insigne to the bench after a hat-trick in Tuesday’s 6-0 mauling of Bologna.
Marek Hamsik makes his 400th appearance in a Napoli jersey, while Pepe Reina is fit to start after shaking off a hip problem.
Roma have a full squad at their disposal, as Antonio Rudiger overcame a slight muscular issue.
Coach Luciano Spalletti goes for a pacey and agile trident attack with Diego Perotti as the False Nine supported by Stephan El Shaarawy and Mohamed Salah, sending Edin Dzeko to the bench.
He’s joined there by Francesco Totti, who has scored three goals in the last two games, all in just 16 minutes of playing time.
These two sides have shared the spoils only once in their last seven Serie A meetings, home and away, with three wins apiece.
However, the Partenopei haven’t conquered the Olimpico in the top flight since a 2-0 result in February 2011, managing a 2-2 draw and three consecutive defeats.
Roma: Szczesny; Florenzi, Manolas, Rudiger, Digne; Pjanic, Nainggolan, Keita; Salah, Perotti, El Shaarawy
Roma bench: De Sanctis, Castan, Zukanovic, Maicon, Palmieri, Torosidis, Strootman, De Rossi, Vainqueur, Dzeko, Iago Falque, Totti
Napoli: Reina; Hysaj, Albiol, Koulibaly, Ghoulam; Allan, Jorginho, Hamsik; Callejon, Higuain, Mertens
Napoli bench: Gabriel, Rafael, Strinic, Regini, Chiriches, Maggio, David Lopez, Grassi, Valdifiori, El Kaddouri, Insigne, Gabbiadini