Inter are in the Group of Death with Bayern Munich and Barcelona, while Milan face Chelsea, Juventus are in with PSG and Napoli take on Liverpool and Ajax in the Champions League group phase.
The draw was held this evening in Istanbul and the group stage games will run from September 6 to November 2.
It is far more compressed than usual in order to be completed before the break in domestic football for the 2022 World Cup in Qatar in November and December.
The top two in the groups will go through to the Round of 16, while third go into the Europa League knockout round play-offs.
Milan were top seeds after winning the Serie A title, Juventus in Pot 2, while Inter and Napoli were in Pot 3.
The Rossoneri were placed in Group E along with Jorginho and Kalidou Koulibaly’s Chelsea, FC Salzburg and Dinamo Zagreb.
Juventus have a tough draw, as they will face Paris Saint-Germain, who of course have Gianluigi Donnarumma, Marco Verratti and represent the former club of new Bianconeri signing Angel Di Maria.
The group is completed by Benfica and Maccabi Haifa.
Napoli were third seeds and placed in Group A with Liverpool, Ajax and Glasgow Rangers.
Undoubtedly, Inter have the toughest draw, placed with Bayern Munich, Barcelona and Viktoria Plzen.
Group A
Ajax (NED)
Liverpool (ENG)
Napoli (ITA)
Rangers (SCO)
Group B
FC Porto (POR)
Atletico Madrid (ESP)
Bayer Leverkusen (GER)
Club Brugge (BEL)
Group C
Bayern Munich (GER)
Barcelona (ESP)
Inter (ITA)
Viktoria Plzen (CZE)
Group D
Eintracht Frankfurt (GER)
Tottenham (ENG)
Sporting CP (POR)
Olympique Marseille (FRA)
Group E
Milan (ITA)
Chelsea (ENG)
FC Salzburg (AUT)
Dinamo Zagreb (CRO)
Group F
Real Madrid (ESP)
RB Leipzig (GER)
Shakhtar Donetsk (UKR)
Celtic (SCO)
Group G
Manchester City (ENG)
Sevilla (ESP)
Borussia Dortmund (GER)
FC Copenhagen (DEN)
Group H
Paris Saint-Germain (FRA)
Juventus (ITA)
Benfica (POR)
Maccabi Haifa (ISR)