Roma move Alessandro Florenzi to a more advanced role in place of Cengiz Under, while Lazio are expected to start Luis Alberto.
It kicks off at 14.00 UK time (13.00 GMT), click here for a match preview.
The Giallorossi showed off their new 4-2-3-1 formation in Wednesday’s 4-0 victory over Frosinone and stick with it, but Eusebio Di Francesco makes some adjustments.
Roma move Alessandro Florenzi to a more advanced role in place of Cengiz Under, while Lazio are expected to start Luis Alberto.
It kicks off at 14.00 UK time (13.00 GMT), click here for a match preview.
The Giallorossi showed off their new 4-2-3-1 formation in Wednesday’s 4-0 victory over Frosinone and stick with it, but Eusebio Di Francesco makes some adjustments.
Davide Santon remains at right-back, but Florenzi returns from being rested in a new position on the right side of the supporting trident.
He flanks Javier Pastore and Stephan El Shaarawy, with Edin Dzeko upfront, meaning Cengiz Under is benched after his sensational goal and assist against Frosinone.
It's a new position only to a degree for Florenzi, who in his time has played in midfield or in any role down the right side.
Lazio are more predictable after five consecutive victories between Serie A and the Europa League.
Stefan Radu and Jordan Lukaku are out injured, so Luiz Felipe, Francesco Acerbi and Wallace make up the defence, although Martin Caceres is challenging Wallace.
The only doubt is who will support Ciro Immobile and it looks as if Luis Alberto is able to stave off competition from on-form Felipe Caicedo.
Probable line-ups
Roma (4-2-3-1): Olsen; Santon, Manolas, Fazio, Kolarov; De Rossi, Nzonzi; Florenzi, Pastore, El Shaarawy; Dzeko
Lazio (3-5-1-1): Strakosha; Luiz Felipe, Acerbi, Wallace; Marusic, Parolo, Leiva, Milinkovic-Savic, Lulic; Luis Alberto; Immobile
Ref: Rocchi