Max Allegri and Carlo Ancelotti keep everyone on their toes, but Juventus look set to start Paulo Dybala, while Napoli rely on Dries Mertens.
It kicks off at 17.00 UK time (16.00 GMT), click here for a match preview.
Both tacticians have chopped and changed regularly so far this season, both in terms of personnel and system.
Max Allegri and Carlo Ancelotti keep everyone on their toes, but Juventus look set to start Paulo Dybala, while Napoli rely on Dries Mertens.
It kicks off at 17.00 UK time (16.00 GMT), click here for a match preview.
Both tacticians have chopped and changed regularly so far this season, both in terms of personnel and system.
According to the latest reports, Paulo Dybala will get the nod rather than Federico Bernardeschi in a 4-3-3 formation with Cristiano Ronaldo and Mario Mandzukic.
This seems to have taken over from the 3-5-2, which was brought back in the midweek win over Bologna, as Andrea Barzagli returns to the bench.
With Sami Khedira, Mattia De Sciglio, Leonardo Spinazzola and suspended Douglas Costa out, Emre Can is the favourite to complete the midfield with Blaise Matuidi and Miralem Pjanic.
Joao Cancelo has the upper hand over Juan Cuadrado at right-back.
Napoli are missing Alex Meret, Amin Younes, Vlad Chiriches and Faouzi Ghoulam.
Arkadiusz Milik scored twice in the midweek victory over Parma, but he’s expected to sit back down on the bench in favour of Dries Mertens with Lorenzo Insigne.
Ancelotti is embracing the 4-4-2 formation, which gives more protection to the defence, with Jose Callejon and Simone Verdi as the wingers.
The only difference from the line-up that beat Torino comfortably a week ago will be Mario Rui stepping in for youth team product Sebastiano Luperto at left-back.
Probable line-ups
Juventus (4-3-3): Szczesny; Cancelo, Bonucci, Chiellini, Alex Sandro; Can, Pjanic, Matuidi; Dybala, Mandzukic, Ronaldo
Napoli (4-4-2): Ospina; Hysaj, Albiol, Koulibaly, Mario Rui; Callejon, Allan, Hamsik, Verdi; Insigne, Mertens