Napoli look to Gonzalo Higuain and Gabriel, as they must end their Udinese taboo to keep up with Juventus.
It kicks off at 11.30 UK time (10.30 GMT), click here for a match preview.
Juve already secured their victory, beating Empoli 1-0 last night thanks to a Mario Mandzukic goal, so the pressure is on the Partenopei to respond.
There were big doubts over whether Reina could feature after sustaining a calf problem in training, and he is on the bench in favour of Brazilian Gabriel.
Napoli look to Gonzalo Higuain and Gabriel, as they must end their Udinese taboo to keep up with Juventus.
It kicks off at 11.30 UK time (10.30 GMT), click here for a match preview.
Juve already secured their victory, beating Empoli 1-0 last night thanks to a Mario Mandzukic goal, so the pressure is on the Partenopei to respond.
There were big doubts over whether Reina could feature after sustaining a calf problem in training, and he is on the bench in favour of Brazilian Gabriel.
Higuain’s extraordinary exploits seem even more remarkable when you consider he alone has scored 29 Serie A goals this season – all of Udinese put together got 26.
The Friulani are hovering just above the relegation zone and hope new Coach Gigi De Canio can revive their fortunes quickly.
He has to do without Antonio Di Natale, who once again misses this clash with his hometown club, Guilherme and Alexander Merkel.
It’s a special occasion for Duvan Zapata and Pablo Armero, who face their former teammates, as does Napoli midfielder Allan.
Napoli have a fairly poor record in Udine, winning only four of their total 33 Serie A visits and losing 12.
They were beaten here 1-0 last season and haven’t won in Friuli since a 5-0 thrashing in September 2007, followed by four draws and three defeats.
Udinese: Karnezis; Heurtaux, Danilo, Felipe; Widmer, Kuzmanovic, Badu, Armero, Fernandes; Thereau, Duvan Zapata
Udinese bench: Meret, Wague, Edenilson, Pasquale, Ali Adnan, Piris, Hallfredsson, Lodi, Iniguez, Balic, Perica, Matos
Napoli: Gabriel; Hysaj, Albiol, Koulibaly, Ghoulam; Allan, Jorginho, Hamsik; Callejon, Higuain, Insigne
Napoli bench: Rafael, Reina, Strinic, Maggio, Regini, Chiriches, Valdifiori, David Lopez, El Kaddouri, Chalobah, Mertens, Gabbiadini