Napoli are in Russia for the fifth match in the Europa League group stage, without Lorenzo Insigne, Zambo Anguissa and Victor Osimhen in the starting line-up.
The match kicks off at 15.30 UK time. Join us for the build-up and action as it happens on the Liveblog.
The Partenopei are first in Group C of the Europa League, but still have a lot of work to ensure a place in the knockout stages.
The group is completely open, with only three points separating first from bottom with two games remaining.
Luciano Spalletti has some worries ahead, as Nigerian striker Osimhen has been ruled out after the clash with Inter defender Milan Skriniar in the last league match.
The striker will be ruled out for months and is set to miss the African Cup of Nations too this winter. In the middle of the park, he will have to replace Zambo Anguissa too, who also suffered an injury in the 3-2 defeat to the Nerazzurri.
Napoli arrive for the match in Russia after their first loss in the League and aim to bounce back immediately and take one step closer to the next round of the competition.
Spalletti has decided to play Andrea Petagna as a lone striker up front, supported by an attacking trident with Hirving Lozano, Dries Mertens and Eljif Elmas.
Piotr Zielinski drops down into the midfield next to Stanislav Lobotka in Anguissa’s absence, while Kalidou Koulibaly and Juan Jesus start in the heart of the defence.
Line-ups: Spartak Moscow vs. Napoli
Spartak Moscow (4-3-3): Selikhov; Caufriez, Dzhikiya, Gogot, Ayrton; Ignatov, Umyarov, Litvinov; Moses, Sobolev, Promes.
Napoli (4-2-3-1): Meret; Di Lorenzo, Koulibaly, Jesus, Mario Rui; Lobotka, Zielinski; Lozano, Mertens, Elmas; Petagna