Milan’s injury crisis continues, so Ante Rebic leads the attack and Ismael Bennacer steps into midfield against an Atletico Madrid, who bench Rodrigo De Paul and Antoine Griezmann.
It kicks off at San Siro at 20.00 UK time (19.00 GMT).
Champions League Liveblog: Shakhtar-Inter, Milan-Atletico Madrid
The Rossoneri lost their opener in a 3-2 thriller away to Liverpool, while Atleti were held 0-0 at home by FC Porto in what promises to be a very tight Champions League group.
Stefano Pioli is still dealing with an injury crisis, with Zlatan Ibrahimovic, Simon Kjaer, Rade Krunic and Tiemoue Bakayoko out of action, and Pietro Pellegri not on their UEFA squad list.
Olivier Giroud and Sandro Tonali are not at 100 per cent, so with Atalanta coming up in Serie A this weekend, they are not risked from the start.
Davide Calabria returns at right-back, with Bennacer in midfield, Alexis Saelemaekers, Brahim Diaz and Rafael Leao supporting Rebic.
Diego Simeone’s Atletico Madrid won LaLiga last season, but their form hasn’t been quite as strong so far this term.
Former Udinese midfielder De Paul and Griezmann are left on the bench, with Stefan Savic is out injured in defence.
It’s a very defensive starting XI at San Siro, with Angel Correa partnering Luis Suarez.
Milan: Maignan; Calabria, Tomori, Romagnoli, Theo Hernandez; Kessie, Bennacer; Saelemaekers, Brahim Diaz, Leao; Rebic
Milan bench: Tatarusanu, Jungdal, Ballo, Tonali, Giroud, Kalulu, Florenzi, Maldini, Gabbia
Atletico Madrid: Oblak; Trippier, Felipe, Gimenez, Hermoso; M Llorente, Koke, Kondogbia, Carrasco; Suarez, Correa
Atletico Madrid bench: Lecomte, Christian, De Paul, Joao Felix, Griezmann, Lemar, Renan Lodi, Herrera, Matheus Cunha, Vrsaljko, Camus,
Ref: Cakir (TUR)