It is not only the Derby della Madonnina, but also a Scudetto showdown between the current joint leaders and the reigning champions, currently two of the top three.
Inter have changed a great deal since Antonio Conte lifted the Serie A trophy only six months ago, but Simone Inzaghi is nonetheless keeping up the momentum from last season and doing even better in the Champions League than his predecessor.
As for Milan, Stefano Pioli continues to build the project and remains unbeaten in Serie A this term, despite the on-going injury crisis. Although the treatment table is emptying out a little, Theo Hernandez is suspended following his red card against Roma.
Expect an incredibly fiery reception for Hakan Calhanoglu, who is the favourite to start in midfield rather than Arturo Vidal against the club he left as a free agent over the summer.
It is the first time since November 2016 that Milan go into the derby with at least a seven-point advantage over their neighbours.
Form Guide: Milan (W W W W W) Inter (W W D L W)
Stat fact: Milan have lost each of the last three Serie A ‘home’ derbies and haven’t made it four in a row since the 1929-34 period.
Probable line-ups
Milan (4-2-3-1): Tatarusanu; Calabria, Kjaer, Tomori, Ballo-Toure; Tonali, Kessie; Saelemaekers, Brahim Diaz, Leao; Ibrahimovic
Suspended: Theo Hernandez
Injured: Maignan, Plizzari, Messias, Castillejo
On a yellow card: None
Inter (3-5-2): Handanovic; Skriniar, De Vrij, Bastoni; Darmian, Barella, Brozovic, Calhanoglu, Perisic; Dzeko, Lautaro Martinez
Suspended: None
Injured: None
On a yellow card: None