Juventus start Arkadiusz Milik against his former club with Federico Chiesa and Angel Di Maria, while Napoli trust Victor Osimhen and Kvicha Kvaratskhelia in this top of the table showdown.
It kicks off at the Stadio Diego Armando Maradona in Naples at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
There are seven points separating the leaders from second place, which is why the Partenopei are already crowned Winter Champions with two rounds to spare.
Luciano Spalletti has a full squad to choose from and goes with Osimhen supported by Kvaratskhelia and Matteo Politano, leaving Giacomo Raspadori on the bench.
Juve are still missing Leonardo Bonucci, Dusan Vlahovic, Juan Cuadrado, Mattia De Sciglio, Paul Pogba and Kaio Jorge, but Gleison Bremer is back in the squad.
Despite all that, they are the form side in Serie A with eight straight wins, all keeping clean sheets.
Federico Chiesa is slowly getting back to fitness a year after his anterior cruciate ligament tear and makes his first start since that devastating blow.
He was supposed to be in competition with Weston McKennie, but instead it is Nicolò Fagioli who is dropped.
Di Maria supports former Napoli striker Milik upfront.
Napoli: Meret; Di Lorenzo, Rrahmani, Kim Min-jae, Mario Rui; Anguissa, Lobotka, Zielinski; Politano, Osimhen, Kvaratskhelia
Juventus: Szczesny; Danilo, Bremer, Alex Sandro; Chiesa, McKennie, Locatelli, Rabiot, Kostic; Di Maria, Milik