Milan are forced to reshuffle amid an injury crisis in Empoli, but have Rafael Leao back with Olivier Giroud upfront.
It kicks off at the Stadio Castellani at 19.45 UK time (18.45 GMT).
The Rossoneri lost 2-1 to Napoli going into the break for international duty, ending a 22-match unbeaten Serie A run.
Injuries are piling up again, losing Mike Maignan, Junior Messias and Theo Hernandez, adding to long-term absentees Divock Origi, Zlatan Ibrahimovic and Alessandro Florenzi.
Ante Rebic is back on the bench and Leao returns after suspension to lead the way with the indefatigable Olivier Giroud, who also started both his Nations League matches for France.
Sandro Tonali and Davide Calabria are available again, with Fode Ballo-Toure and Ciprian Tatarusanu stepping in.
Empoli are fresh from their first victory of the season, 1-0 away to Bologna, but Ardian Ismajli picked up an injury playing for Albania.
Lorenzo Tonelli is still absent, though Mattia Destro and Tommaso Baldanzi are available again.
Empoli: Vicario; Stojanovic, De Winter, Luperto, Parisi; Haas, Henderson, Grassi; Pjaca; Lammers, Satriano
Milan: Tatarusanu; Calabria, Kjaer, Tomori, Ballo-Touré; Bennacer, Tonali; Saelemaekers, De Ketelaere, Leao; Giroud