Paulo Dybala is expected to rest in Roma’s away game at Frosinone, but Stephan El Shaarawy returns to the starting XI.
It kicks off at 17:00 GMT at the Stadio Stirpe.
Frosinone have several players out of action, including the product of Roma academy Riccardo Marchizza and January signing Kevin Bonifazi.
Juventus loanees Enzo Barrenechea and Matias Soulé are expected to start for the hosts, while Kaio Jorge or Walid Cheddira will get the nod in attack.
Roma secured an away 1-1 draw in Europa League against Feyenoord earlier this week and will play the decider in Rome this coming Thursday, so Daniele De Rossi will slightly rotate his squad today.
Diego Llorente should rest, making room for Dean Huijsen in central defence. Leandro Paredes could rest too as Edoardo Bove is favourite to start in central midfield with Bryan Cristante and Lorenzo Pellegrini.
El Shaarawy was introduced in the second half against Feyenoord on Thursday but will start against Frosinone, while Dybala will rest so Tommaso Baldanzi can start his first-ever game for the Giallorossi.
Tammy Abraham is the only injured player for Roma at the Stadio Stirpe.
Frosinone-Roma: Probable line-ups
Frosinone (4-3-3): Turati; Lirola, Okoli, Monterisi, Valeri; Mazzitelli, Barrenechea, Gelli; Soulé, Kaio Jorge, Harroui.
Roma (4-3-2-1): Rui Patricio; Karsdorp, Mancini, Huijsen, Angelino; Bove, Cristante, Pellegrini; Baldanzi, El Shaarawy; Lukaku.