Napoli have a remarkable Serie A record away to Milan, losing only one of their last 11 visits, and could make it three wins in a row here for the first time since 1979.
It kicks off at San Siro on Sunday at 19.45 UK time (18.45 GMT).
This is a Scudetto head-to-head between joint leaders, along with Atalanta, all going into the weekend on 14 points.
Stefano Pioli’s men have a very strong home record, winning their last six games here, and are unbeaten in 22 Serie A fixtures in total.
However, Napoli are an exception and have lost only one of their last 11 League visits to the Stadio Meazza, 2-0 in December 2014.
That is the lone outlier in a run of five Napoli victories and five stalemates.
The Partenopei have won the last two editions of this fixture, both by 1-0 results in March and December 2021.
It could therefore be the first time Milan have lost three consecutive Serie A home games against Napoli since 1979.
The most remarkable encounter was a 4-0 Napoli victory in October 2015, sealed by Allan, a Lorenzo Insigne brace and Rodrigo Ely own goal for Maurizio Sarri’s side.