Luis Alberto has not made the trip due to a muscular problem, so Maurizio Sarri has to completely transform his Lazio midfield against Sassuolo.
The Aquile are already fatigued after Thursday’s 0-0 draw with Galatasaray saw them miss out on direct passage to the Europa League Round of 16.
Sergej Milinkovic-Savic was sent off against Sampdoria last week and therefore has to sit out a one-match Serie A ban.
Luis Alberto is not going to make the trip to the Mapei Stadium in Reggio-Emilia either, as he did not train on Friday or today due to a muscular problem.
Danilo Cataldi therefore should step in with Toma Basic and Jean-Daniel Akpa-Akpro, although the latter is not 100 per cent fit either and didn’t train with the rest of the team yesterday.
Lucas Leiva is another option for the middle of the park, while Mattia Zaccagni is capable of a midfield role if needed.
Ciro Immobile has been nursing a right knee issue for several weeks, but he grits his teeth and plays on.