Juventus have the chance to go nine points clear at the top, but have midfield problems against Antonio Di Natale’s Udinese.
It kicks off at 14.00 GMT at the Stadio Friuli, click here for a match preview.
Roma are in crisis and their fourth consecutive draw, 1-1 with Empoli last night, means Juve can consolidate their Serie A leadership.
Max Allegri is forced into some changes, as Claudio Marchisio is suspended with Arturo Vidal, Kwadwo Asamoah and Romulo injured.
Juventus have the chance to go nine points clear at the top, but have midfield problems against Antonio Di Natale’s Udinese.
It kicks off at 14.00 GMT at the Stadio Friuli, click here for a match preview.
Roma are in crisis and their fourth consecutive draw, 1-1 with Empoli last night, means Juve can consolidate their Serie A leadership.
Max Allegri is forced into some changes, as Claudio Marchisio is suspended with Arturo Vidal, Kwadwo Asamoah and Romulo injured.
Sebastian Giovinco was not called up, fuelling reports he will terminate his contract early to join Toronto FC.
Allegri looks as if he is changing to a 3-5-2 system for this fixture.
The Bianconeri needed an 89th-minute Alvaro Morata goal to get the better of Parma in the Coppa Italia quarter-final midweek and looked far from sharp.
Roberto Pereyra gets the chance to play against his former teammates.
Udinese have numerous absentees too, as Panagiotis Kone begins a three-match ban.
Giampiero Pinzi, Alexandre Geijo, Emmanuel Badu, Maurizio Domizzi, Molla Wague and Lucas Evangelista are all unavailable.
Di Natale leads the way, as always, with support from Cyril Thereau.
In the last four Serie A home games against Juventus, Udinese have scored one goal and suffered three defeats.
Udinese: Karnezis; Heurtaux, Danilo, Piris, Gabriel Silva, Allan, Bruno Fernandes, Guilherme, Widmer; Di Natale, Thereau
Juventus: Buffon; Caceres, Bonucci, Chiellini; Lichtsteiner, Pereyra, Pirlo, Pogba, Evra; Tevez, Llorente
Juventus bench: Storari, Rubinho, Barzagli, Ogbonna, De Ceglie, Padoin, Pepe, Coman, Morata