It’s a head-to-head for Roma and Manchester City, as only one can progress in the Champions League.
It kicks off at the Stadio Olimpico at 19.45 GMT and finds Roma, City and CSKA Moscow locked together on five points.
The Giallorossi will go through with a win or a draw if CSKA Moscow share the points with already-qualified Bayern Munich.
If CSKA lose in Germany, then the Italians progress with a 0-0 draw, but not a score draw.
It’s a head-to-head for Roma and Manchester City, as only one can progress in the Champions League.
It kicks off at the Stadio Olimpico at 19.45 GMT and finds Roma, City and CSKA Moscow locked together on five points.
The Giallorossi will go through with a win or a draw if CSKA Moscow share the points with already-qualified Bayern Munich.
If CSKA lose in Germany, then the Italians progress with a 0-0 draw, but not a score draw.
This is because Roma have a superior head-to-head record with CSKA, but the Russians are better in their direct confrontations with City.
Rudi Garcia said this match is “like a final” and the Group of Death does, as expected, go down to the wire.
Leandro Castan and Vasilis Torosidis are out injured, but Francesco Totti, Gervinho and Adem Ljajic start in the 4-3-3 formation. Castan will be in the stands for the first time since undergoing brain surgery to remove a cavernoma a week ago.
Daniele De Rossi is ‘rested’ in favour of Seydou Keita and Miralem Pjanic after his red card against Sassuolo and a tough week off the field.
Douglas Maicon takes the right-back slot with Jose Holebas on the left, meaning Ashley Cole isn’t even on the bench.
Manchester City are without star striker Sergio Aguero, who will be out for four to eight weeks with a knee ligament injury.
It’s a huge blow for them, as he has scored 19 goals in 20 games between the Premier League and Champions League this season. He also netted five of their total seven goals in Europe.
Yaya Toure is suspended in midfield so won’t get to face Ivory Coast teammate Gervinho, while Matija Nastasic and Vincent Kompany are sidelined.
David Silva and Stevan Jovetic were also carrying knocks, so are only on the bench.
Edin Dzeko therefore takes the centre-forward role supported by Samir Nasri, Jesus Navas and James Milner.
Roma would’ve needed only a draw here if they had held on to their lead away to CSKA Moscow for 20 more seconds, but were pegged back 1-1.
Premier League teams have lost in their last three visits to the Olimpico, while the Citizens have never won on Italian soil with two draws and as many defeats.
These sides drew 1-1 at the Etihad back in September, with Maicon giving away an early penalty and Totti on target thanks to a delightful lob.
The referee is Serbian Milorad Mazic.
Roma: De Sanctis; Maicon, Yanga-Mbiwa, Manolas, Holebas; Pjanic, Keita, Nainggolan; Gervinho, Totti, Ljajic
Roma bench: Curci, Astori, Strootman, Florenzi, De Rossi, Iturbe, Destro
Manchester City: Hart; Zabaleta, Demichelis, Mangala, Clichy; Fernando, Fernandinho; Navas, Nasri, Milner; Dzeko
Man City bench: Caballero, Sagna, Kolarov, Lampard, Boyata, Silva, Jovetic