Roma hope to turn their season around, but begin the Europa League experience against Dutch side Feyenoord.
It kicks off at the Stadio Olimpico at 18.00 GMT and is the first leg in a Round of 32.
The Giallorossi have been struggling ever since their Champions League elimination at the hands of Manchester City in December.
The campaign had started so well with a demolition of CSKA Moscow, but after that they failed to win any of the remaining five in the group phase.
Roma hope to turn their season around, but begin the Europa League experience against Dutch side Feyenoord.
It kicks off at the Stadio Olimpico at 18.00 GMT and is the first leg in a Round of 32.
The Giallorossi have been struggling ever since their Champions League elimination at the hands of Manchester City in December.
The campaign had started so well with a demolition of CSKA Moscow, but after that they failed to win any of the remaining five in the group phase.
They have drawn five on the bounce at the Olimpico in Serie A, including Sunday’s desperately disappointing 0-0 against bottom of the table Parma.
Injury problems persist with Victor Ibarbo, Juan Manuel Iturbe, Kevin Strootman, Douglas Maicon and Leandro Castan sidelined.
Coach Rudi Garcia will be hoping for an early celebration, as tomorrow is his 51st birthday.
As Seydou Doumbia seemed shaky on his debut at the weekend, the new arrival is benched in favour of 18-year-old sensation Daniele Verde on his European debut.
Gervinho completes the trident attack with Francesco Totti.
Feyenoord hadn’t won on their continental travels for 10 games – including nine defeats – before a 3-0 victory at Standard Liege in December.
The Dutch side does not traditionally impress in Europe, failing to win a UEFA match in spring since 2002.
Defender Sven van Beek is out injured.
Tension in the city is sky high, as drunk Feyenoord fans have been wreaking havoc since last night, holding pitched battles with police and trashing historic monuments.
Roma: Skorupski; Torosidis, Manolas, Yanga-Mbiwa, Holebas; Nainggolan, De Rossi, Pjanic; Gervinho, Totti, Verde
Roma bench: De Sanctis, Astori, Keita, Florenzi, Paredes, Ljajic, Doumbia
Feyenoord: Vermeer; Wilkshire, Boulahrouz, Kongolo, Nelom; El Ahmadi, Immers, Clasie; Toornstra, Kazim Kazim, Trindade de Vilhena
Feyenoord bench: Mulder, Mathijsen, Woudenberg, Karsdorp, Boetius, Te Vrede, Achahbar