Dries Mertens and Hirving Lozano take on RB Salzburg’s Erling Haaland, but Napoli have defender Kostas Manolas on the bench.
It kicks off at the Stadio San Paolo at 20.00 GMT.
You can follow all the build-up and action as it happens from this game and Borussia Dortmund-Inter on the LIVEBLOG.
Dries Mertens and Hirving Lozano take on RB Salzburg’s Erling Haaland, but Napoli have defender Kostas Manolas on the bench.
It kicks off at the Stadio San Paolo at 20.00 GMT.
You can follow all the build-up and action as it happens from this game and Borussia Dortmund-Inter on the LIVEBLOG.
The Partenopei’s thrilling 3-2 victory in Austria has put them in pole position to qualify from Group E and they will be through tonight if they win and Genk fail to beat Liverpool.
Allan is not even fit for the bench, but Manolas is not ready to start, as the centre-back is still suffering from bruised ribs and had to play with painkillers.
Nikola Maksimovic partners Kalidou Koulibaly at centre-back.
Mertens and Lozano are the front two, with Lorenzo Insigne and Jose Callejon out wide, despite Arkadiusz Milik’s positive form.
RB Salzburg have built most of their success this season on the astonishing form of teenage striker Erling Haaland, who has 22 goals in just 16 competitive games this season.
That includes six in three Champions League matches.
He has support from Hee-Chan Hwang, but Takumi Minamino is also a danger with his pace.
Carlos Miguel Coronel is in goal after Cican Stankovic pulled a hamstring against Napoli on October 23.
Napoli: Meret; Di Lorenzo, Maksimovic, Koulibaly, Mario Rui; Callejon, Fabian Ruiz, Zielinski, Insigne; Lozano, Mertens
Napoli bench: Ospina, Llorente, Elmas, Luperto, Hysaj, Manolas, Milik
RB Salzburg: Coronel; Pongracic, Onguéné, Wober; Kristensen, Minamino, Junuzovic, Szoboszlai, Ulmer; Haaland, Hwang
Salzburg bench: Kohn, Ashimeru, Vallci, Koita, Ramalho, Daka, Mwepu
Ref: Marciniak