Napoli have their sights set on second place, but welcome an Udinese side that held them 2-2 in the Coppa Italia.
It kicks off at the Stadio San Paolo at 14.00 GMT, click here for our LIVEBLOG coverage.
The Partenopei have won all but one of their Serie A matches in 2015 and are raring up the standings, just four points adrift of Roma.
Second place is particularly important in Italy, as third only guarantees a spot in the Champions League preliminary round.
Napoli have their sights set on second place, but welcome an Udinese side that held them 2-2 in the Coppa Italia.
It kicks off at the Stadio San Paolo at 14.00 GMT, click here for our LIVEBLOG coverage.
The Partenopei have won all but one of their Serie A matches in 2015 and are raring up the standings, just four points adrift of Roma.
Second place is particularly important in Italy, as third only guarantees a spot in the Champions League preliminary round.
Kalidou Koulibaly is suspended with Giandomenico Mesto, Lorenzo Insigne, Juan Camilo Zuniga and Michu injured.
Gonzalo Higuain leads the way, as always, supported this time by Manolo Gabbiadini, Marek Hamsik and Dries Mertens.
Udinese held Juventus to a draw last week and were at the San Paolo in the Coppa Italia in January, managing a 2-2 result in extra time despite being down to 10 men.
The Friulani eventually capitulated only at the end of a tense penalty shoot-out.
Panagiotis Kone was on target that day, but he is suspended along with captain Antonio Di Natale.
Also absent are Giampiero Pinzi, Alexandre Geijo, Emmanuel Badu, Maurizio Domizzi and Luca Evangelista.
Paolo Silvio Mazzoleni was originally meant to officiate this game, but pulled out as his wife is about to give labour, so Marco Di Bello takes over.
Napoli: Rafael; Maggio, Albiol, Britos, Ghoulam; Gargano, Inler; Mertens, Hamsik, Gabbiadini; Higuain
Udinese: Karnezis; Piris, Danilo, Heurtaux; Widmer, Allan, Hallberg, Guilherme, Pasquale; Fernandes, Thereau