Milan rely on Patrick Cutrone after a Nikola Kalinic injury, while Lazio look to Felipe Caicedo and Luis Alberto in Ciro Immobile’s absence.
It kicks off at San Siro at 17.00 GMT, follow all the build-up and action as it happens on the LIVEBLOG.
Curiously, these sides will meet again on Wednesday night in the first leg of the Coppa Italia semi-final.
Milan rely on Patrick Cutrone after a Nikola Kalinic injury, while Lazio look to Felipe Caicedo and Luis Alberto in Ciro Immobile’s absence.
It kicks off at San Siro at 17.00 GMT, follow all the build-up and action as it happens on the LIVEBLOG.
Curiously, these sides will meet again on Wednesday night in the first leg of the Coppa Italia semi-final.
The Rossoneri have been improving in recent weeks, but the 4-1 defeat at the Olimpico in September was one of the main reasons why Vincenzo Montella was sacked to make way for Gennaro Gattuso.
Ricardo Rodriguez is suspended with Andrea Conti still injured, Davide Calabria and Luca Antonelli are the full-backs.
Kalinic picked up a small injury in training yesterday, so Cutrone is chosen rather than Andre Silva to lead the attack with Suso and Hakan Calhanoglu.
It’s a special game for Lucas Biglia, although Lazio have replaced him more than admirably with Lucas Leiva.
Capocannoniere Immobile has 20 Serie A goals this season, but he’s not even on the bench due to a muscular issue.
Felipe Caicedo is picked rather than Felipe Anderson or Luis Nani to start in his place with support from Luis Alberto and Sergej Milinkovic-Savic.
Lazio have only ever won nine Serie A trips to San Siro, along with 23 draws and 42 defeats. Their last victory here in the top flight was 1-0 in September 1989, incredibly decided by a Paolo Maldini own goal, followed by 11 draws and 16 defeats.
Milan: G Donnarumma; Calabria, Bonucci, Romagnoli, Antonelli; Kessie, Biglia, Bonaventura; Suso, Cutrone, Calhanoglu
Milan bench: A Donnarumma, Gabriel, Musacchio, Paletta, Abate, Zapata, Locatelli, Montolivo, Borini, Kalinic, André Silva
Lazio: Strakosha; Bastos, De Vrij, Radu; Marusic, Parolo, Leiva, Milinkovic-Savic, Lulic; Luis Alberto; Caicedo
Lazio bench: Vargic, Guerrieri, Patric, Wallace, Caceres, Luiz Felipe, Basta, Jordao, Murgia, Lukaku, Felipe Anderson, Nani