Mauro Icardi, Ivan Perisic and Stevan Jovetic face Alvaro Morata, Simone Zaza and Paul Pogba in the Derby d’Italia.
It kicks off at 19.45 UK time (18.45 GMT), follow the action and build-up on our LIVEBLOG.
Inter are without Adem Ljajic after he picked up an injury on international duty with Serbia, while Stevan Jovetic is not 100 per cent fit either, but still starts.
He completes the trident attack with Ivan Perisic and the anti-Juve hitman Mauro Icardi.
Mauro Icardi, Ivan Perisic and Stevan Jovetic face Alvaro Morata, Simone Zaza and Paul Pogba in the Derby d’Italia.
It kicks off at 19.45 UK time (18.45 GMT), follow the action and build-up on our LIVEBLOG.
Inter are without Adem Ljajic after he picked up an injury on international duty with Serbia, while Stevan Jovetic is not 100 per cent fit either, but still starts.
He completes the trident attack with Ivan Perisic and the anti-Juve hitman Mauro Icardi.
The return of Joao Miranda and Jeison Murillo in defence means Gary Medel is pushed forward into midfield, benching Geoffrey Kondogbia.
Marcelo Brozovic is surprisingly given the nod ahead of Fredy Guarin.
As for Juventus, they are without Stephan Lichtsteiner and Martin Caceres.
Paul Pogba, Alvaro Morata and Roberto Pereyra all picked up injuries on international duty, but are passed fit.
It is the first time Max Allegri has been able to use his first choice midfield with Claudio Marchisio, Sami Khedira and Pogba.
Paulo Dybala had been tipped to partner Morata, as Mario Mandzukic is not 100 per cent fit, but Zaza surprisingly won his place instead.
Inter: Handanovic; Santon, Miranda, Murillo, Juan Jesus; Medel, Melo, Brozovic; Perisic, Jovetic, Icardi
Inter bench: Carrizo, Berni, Kondogbia, Palacio, Biabiany, Telles, Guarin, Montoya, Ranocchia, Gnoukouri, D'Ambrosio, Nagatomo, Manaj
Juventus: Buffon; Barzagli, Bonucci, Chiellini; Cuadrado, Khedira, Marchisio, Pogba, Evra; Zaza, Morata
Juventus bench: Neto, Audero, Hernanes, Alex Sandro, Mandzukic, Lemina, Padoin, Dybala, Asamoah, Rugani, Sturaro, Pereyra