Arkadiusz Milik, Piotr Zielinski and Marek Hamsik start with Lorenzo Insigne, as Napoli visit Krzysztof Piatek’s struggling Genoa.
It kicks off at Marassi at 19.30 GMT, follow the build-up and action as it happens on the LIVEBLOG.
The Partenopei lost one of only two games this season in this stadium, falling 3-0 to Sampdoria.
Arkadiusz Milik, Piotr Zielinski and Marek Hamsik start with Lorenzo Insigne, as Napoli visit Krzysztof Piatek’s struggling Genoa.
It kicks off at Marassi at 19.30 GMT, follow the build-up and action as it happens on the LIVEBLOG.
The Partenopei lost one of only two games this season in this stadium, falling 3-0 to Sampdoria.
Carlo Ancelotti’s men held Paris Saint-Germain to another draw in the Champions League midweek and flattened Empoli 5-1 last Saturday with a Dries Mertens hat-trick.
As the Belgian hurt his shoulder, he is rested in favour of Poland international Milik, who is up against his fellow countryman Piatek this evening.
Simone Verdi, Vlad Chiriches, Alex Meret and Amin Younes are injured, but there is no predicted rest for Allan, Mario Rui or Elseid Hysaj.
Genoa are in crisis and there are already reports Coach Ivan Juric could be sacked just a month after replacing Davide Ballardini.
That decision did not go down well with the ultras, who are planning a protest against President Enrico Preziosi this evening.
Juric held Juventus to a 1-1 draw on his debut, but it’s been all downhill from there, culminating in a 5-0 defeat to Inter.
Midfielder Sandro is out injured along with Federico Marchetti, Nicolas Spolli, Andrea Favilli and Andrea Dalmonte.
Domenico Criscito returns from suspension to face his hometown club, while Piatek remains Capocannoniere despite firing blanks in his last four games.
He was surprisingly benched for the 5-0 loss to Inter, playing only 39 minutes, and his last goal was in a 3-1 home defeat to Parma on October 7.
Genoa, meanwhile, have managed just two draws and three defeats since their most recent victory, 2-1 away to Frosinone on September 30.
Miguel Veloso gets his first start since returning to the club last month, having been signed as a free agent.
Napoli are unbeaten in their last 12 Serie A meetings with Genoa, home and away, winning nine and drawing three. Their last defeat was 3-2 at Marassi on January 29, 2012.
Genoa: Radu; Biraschi, Romero, Criscito; Lazovic, Hiljemark, Veloso, Romulo, Bessa; Piatek, Kouame
Genoa bench: Russo, Gunter, Lisandro Lopez, Lapadula, Mazzitelli, Rolon, Pandev, Pereira, Lakicevic, Omeonga, Medeiros, Zukanovic
Napoli: Ospina; Hysaj, Albiol, Koulibaly, Mario Rui; Callejon, Allan, Hamsik, Zielinski; Milik, Insigne
Napoli bench: Karnezis, D’Andrea, Maksimovic, Ghoulam, Luperto, Malcuit, Fabian, Rog, Diawara, Mertens, Ounas
Ref: Abisso