Gian Piero Gasperini decided to start Gianluca Scamacca over Charles De Ketelaere for Atalanta in the first leg of their Europa League Round of 16 tie with Sporting.
The action kicks off at 17.45 UK time at the José Alvalade Stadium in Lisbon.
You can follow all the build-up and action as it happens on the Liveblog.
Atalanta looked solid in their two Europa League group stage meetings with Sporting earlier this season, picking up a 1-1 draw at home and edging out a 2-1 win away as they topped Group D.
La Dea have a fully fit squad heading into the match, giving Gasperini options across the pitch.
Sporting have a handful of injuries to contend with, having to face Atalanta without Pedro Goncalves, Trincao, Goncalo Inacio and Antonio Adan.
The Verde e Brancos have been in strong form in the Primeira Liga in recent weeks, picking up four wins in their last five matches, including an 8-0 thrashing of Casa Pia.
Sporting vs Atalanta – starting line-ups
Sporting CP (3-4-2-1): Israel; Quaresma, Coates, Diomande; Catamo, Koindredi, Morita, Reis; Edwards, Trincao; Paulinho.
Atalanta (3-4-2-1): Musso; Djimsiti, Hien, Kolasinac; Holm, Ederson, De Roon, Ruggeri; Miranchuk, Lookman; Scamacca.