Italy have a makeshift defence for the World Cup play-off with North Macedonia, relying on Ciro Immobile, Domenico Berardi and Lorenzo Insigne upfront.
It kicks off at the Stadio Barbera in Palermo at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The winners of this tie go on to face either Portugal or Turkey in the Final on Tuesday for a spot at the 2022 World Cup in Qatar.
Roberto Mancini is missing quite a few players who helped the Azzurri to glory at EURO 2020 last summer, including Federico Chiesa, Leonardo Spinazzola, Giovanni Di Lorenzo and Leonardo Bonucci.
Giorgio Chiellini is only fit for a spot on the bench, so it’s a totally revamped back four with Alessandro Florenzi, Gianluca Mancini, Alessandro Bastoni and Emerson Palmieri.
The midfield remains untouched, although it is not clear if Jorginho will take the penalties after his two very costly errors against Switzerland in qualifying.
Immobile leads the attack flanked by Berardi and Insigne, while Gianluca Scamacca, Andrea Belotti and Nicolò Zaniolo are not even available on the bench due to minor fitness concerns.
North Macedonia finished runners-up in their qualifying group to Germany, despite managing a victory away to Die Mannschaft.
Goran Pandev has retired from international duty, so Milan Ristovski leads the way, with former Palermo striker Aleksandar Trajkovski feeling very much at home in this stadium.
Napoli midfielder Eljif Elmas sits out a ban and is a major loss for the Macedonian squad.
Italy: Donnarumma; Florenzi, Bastoni, Mancini, Emerson; Barella, Jorginho, Verratti; Berardi, Immobile, Insigne
Italy bench: Sirigu, Cragno, De Sciglio, Chiellini, Tonali, Cristante, Pellegrini, Joao Pedro, Pessina, Acerbi, Politano, Raspadori
North Macedonia: Dimitrievski; S Ristovski, D Velkovski, Musliu, Alioski; Ademi, Bardi, Nikolov; Churlinov, M Ristovski, Trajkovski
N Macedonia bench: Naumovski, Siskovski, Todoroski, Ashkovski, Ristevski, D Babynski, Serafimov, Ethemi, Babunski, Spirovski, Atanasov, Miovski
Ref: Turpin (FRA)