Ciro Immobile’s injury complicates matters for Italy going into the crucial World Cup qualifier with Switzerland, so how could Roberto Mancini’s men set up?
The big game kicks off at the Stadio Olimpico in Rome at 19.45 GMT on Friday.
Italy and Switzerland are joint leaders on 14 points, but the Azzurri have a superior goal difference of +11 to +9.
Lazio striker Immobile left the training camp today after a soleus muscle strain, joining Nicolò Zaniolo and Lorenzo Pellegrini in pulling out of the squad.
Andrea Belotti is nowhere near fully fit after an ankle sprain for Torino, while Sassuolo’s Gianluca Scamacca has been called in as a replacement for Immobile.
The most likely alternative for Mancini is to set the Azzurri out in a 4-3-3 formation with a ‘lightweight’ trident attack.
That would move Federico Chiesa or Lorenzo Insigne to the centre-forward role, with Domenico Berardi completing the trio.
With Chiesa and Insigne together, they could swap places during the match to keep opposition defenders guessing.
Federico Bernardeschi of Juventus and Sassuolo’s Giacomo Raspadori are other options for the False 9, although Raspadori has increasingly been used in a supporting role at club level this season.
Nicolò Barella and Giorgio Chiellini are training separately from the rest of the group due to flexor issues, so they too remain in doubt.