Milan boss Stefano Pioli can never face Fiorentina at the Stadio Franchi without the memories flooding back of Davide Astori, while the fans sided with him over the club owners.
It kicks off at 19.45 GMT, you can follow the build-up and action as it happens on the LIVEBLOG.
Pioli said this can never be a normal game for him, as he had such a strong and unbreakable connection with the Viola players and fans.
It was one forged in tragedy, the sudden death of captain Davide Astori in an Udine hotel room in March 2018, at the age of 31.
The squad was there to prepare for a match against Udinese when he did not come down to breakfast, passing away from an undiagnosed heart condition.
Pioli was credited with keeping the team together and helping them get through the horrific situation, taking on a paternal role for many of the players.
The fans were always grateful for this leadership and clear emotional connection he had with the players.
Pioli was on the Fiorentina bench from June 2017 to April 2019, overseeing 74 competitive matches with 27 wins, 25 draws and 22 defeats.
He resigned after a 1-0 home defeat to Frosinone on April 7, 2019, angered by the public statement released by Fiorentina that urged team and coach to be ‘competent and professional.’
Pioli felt insulted by the suggestion and walked away, creating an irrevocable break between the fans and the owners, the Della Valle brothers.
They would sell the club soon after to Rocco Commisso.
Astori started his career in the Milan youth academy, but never actually played for the club at senior level.
He is remembered during every Fiorentina game, as the fans applaud at the 13th minute, marking his shirt number, DA13.
The symbol is also ever-present on the Fiorentina captain’s armband.