With Ante Rebic and Rafael Leao confirmed out for Milan, Samu Castillejo is tipped to start up front when Manchester United arrive at San Siro.
The match kicks off at 20.00 UK time.
Coach Stefano Pioli is forced to make changes against Manchester United and Castillejo is expected to fill the void after Leao and Rebic were confirmed out.
The two forwards trained partially on Wednesday and were not called up for the match against the Red Devils.
With Ante Rebic and Rafael Leao confirmed out for Milan, Samu Castillejo is tipped to start up front when Manchester United arrive at San Siro.
The match kicks off at 20.00 UK time.
Coach Stefano Pioli is forced to make changes against Manchester United and Castillejo is expected to fill the void after Leao and Rebic were confirmed out.
The two forwards trained partially on Wednesday and were not called up for the match against the Red Devils.
The first match ended in a 1-1 draw at Old Trafford and Pioli has Zlatan Ibrahimovic included in the squad for the decisive leg in Milan tonight.
Ismael Bennacer and Sandro Tonali have been called up, but Soualiho Meite is expected to take place next to Franck Kessie in the middle.
Sky Sport Italia claims Pierre Kalulu could get the nod over United loanee Diogo Dalot at right-back too.
Milan (probable): Donnarumma; Kalulu, Kjaer, Tomori, Theo Hernandez; Meite, Kessie; Saelemaekers, Calhanoglu, Krunic, Castillejo
Man Utd (probable): De Gea; Wan Bissaka, Lindelof, Maguire, Shaw; McTominay, Fred; James, Bruno Fernandes, Greenwood; Rashford
Referee: Brych (GER)