While Portugal lose Rony Lopes to injury, Italy reportedly transform to a 4-4-2 with Simone Zaza and Ciro Immobile together.
The UEFA Nations League match kicks off in Lisbon at 19.45 UK time (18.45 GMT).
Roberto Mancini has cut several players from the squad that drew 1-1 with Poland, removing Mario Balotelli, Cristiano Biraghi, Daniele Rugani, Davide Zappacosta, Lorenzo Pellegrini, Nicolò Zaniolo and Alessio Cragno.
While Portugal lose Rony Lopes to injury, Italy reportedly transform to a 4-4-2 with Simone Zaza and Ciro Immobile together.
The UEFA Nations League match kicks off in Lisbon at 19.45 UK time (18.45 GMT).
Roberto Mancini has cut several players from the squad that drew 1-1 with Poland, removing Mario Balotelli, Cristiano Biraghi, Daniele Rugani, Davide Zappacosta, Lorenzo Pellegrini, Nicolò Zaniolo and Alessio Cragno.
According to the latest reports, only three players will remain from the starting XI that faced Poland on Friday: Gianluigi Donnarumma, Jorginho and Roberto Gagliardini.
The tactical system could also change from 4-3-3 to 4-4-2, with Zaza and Immobile together.
Federico Chiesa and Giacomo Bonaventura can take the wings, with SPAL full-back Manuel Lazzari getting his international debut.
Portugal, on the other hand, are practically unchanged from the side that drew 1-1 with Croatia in Thursday’s friendly.
Raphael Guerreiro pulled out with an injury and Rony Lopes is a late addition to the absentee list, though the Monaco winger had been tipped to start.
Ex-Milan striker Andre Silva can lead the attack with Bernardo Silva, while Juventus and Napoli full-backs Joao Cancelo and Mario Rui represent Serie A.
Cristiano Ronaldo remained behind in Turin to focus on training with his new club Juventus.
Probable line-ups
Portugal (4-1-4-1): Patricio; Cancelo, Pepe, Ruben Dias, Mario Rui; Ruben Neves; William, Pizzi, Bernardo Silva, Gelson; Andre Silva
Italy (4-4-2): Donnarumma; Lazzari, Caldara, Romagnoli, Criscito; Chiesa, Gagliardini, Jorginho, Bonaventura; Zaza, Immobile
Ref: Collum (SCO)