There are even more injury problems piling up for Milan and their trip to Juventus, as Fikayo Tomori could be used as a right-back, with Mike Maignan not guaranteed to start in goal.
It kicks off on Sunday at 19.45 UK time (18.45 GMT) at the Allianz Juventus Stadium in Turin.
Stefano Pioli has huge problems to deal with just days after an energy-sapping 3-2 Champions League defeat away to Liverpool.
There are six players out of action, specifically Zlatan Ibrahimovic, Olivier Giroud, Davide Calabria, Tiemoue Bakayoko, Rade Krunic and Junior Messias.
According to Sky Sport Italia, these are only the players not making the trip, but two others are by no means guaranteed a starting spot.
Maignan saved Mohamed Salah’s penalty at Anfield and landed awkwardly on his left hand.
He was spotted in training on Saturday with strapping around his left wrist and it remains to be seen if he’ll pass a fitness test.
If the Frenchman cannot make it, then Ciprian Tatarusanu will take over the gloves.
The other concern is the right-back, where Alessandro Florenzi was the natural replacement for Calabria.
However, the former Roma veteran is not fully fit either and there are concerns about using him in such an energetic role.
Instead, Pioli reportedly tested out centre-back Tomori on the right, which would allow Milan to defend with three while Theo Hernandez has more freedom to bomb forward down the left.
If confirmed, then this would mean no rest for Simon Kjaer, forming a new partnership with Alessio Romagnoli.