Inter bring Hakan Calhanoglu back into the starting XI with Lautaro Martinez and Alexis Sanchez, while Juventus rely on Alvaro Morata and Dejan Kulusevski in the Supercoppa Italiana.
It kicks off at San Siro at 20.00 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
This is usually a traditional pre-season fixture between the Scudetto winners and Coppa Italia holders, but in recent years has moved to December or January.
Serie A champions Inter go into this game after eight consecutive league victories and with a full squad to choose from.
Edin Dzeko returns after recovering from COVID-19 and partners Lautaro Martinez upfront, with Alexis Sanchez on the bench.
Calhanoglu was suspended for the win over Lazio, but returns here to pull the midfield strings with Marcelo Brozovic and Nicolò Barella.
Coppa Italia holders Juventus have more pressing problems, especially as Matthijs de Ligt and Juan Cuadrado are both suspended after picking up yellow cards in Sunday’s 4-3 Serie A win over Roma.
Federico Chiesa is out for the rest of the season after knee surgery, with Danilo and Aaron Ramsey also out of action.
Wojciech Szczesny is also unavailable because he only just received his first COVID vaccine dose, so is not eligible for a Super Green Pass and therefore cannot enter the locker rooms under new rules, so Mattia Perin is in goal.
Giorgio Chiellini returns in defence, with Leonardo Bonucci still not at 100 per cent after injury, while Kulusevski starts with Morata, leaving Paulo Dybala on the bench in what should be a 4-4-2 formation.
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Dumfries, Calhanoglu, Brozovic, Barella, Perisic; Dzeko, Lautaro Martinez
Juventus: Perin; De Sciglio, Rugani, Chiellini, Alex Sandro; Bernardeschi, McKennie, Locatelli, Rabiot; Kulusevski, Morata
Ref: Doveri
VAR: Mazzoleni
Hattrick by Kulusevski