Lautaro Martinez and Marcus Thuram take on Giovanni Simeone and Kvicha Kvaratskhelia, as Inter and Napoli face off for the Supercoppa Italiana.
It kicks off at the Al-Awwal Park Stadium in Riyadh at 19.00 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The winner will be decided after 90 minutes or go straight to a penalty shoot-out.
Although this is the first Final Four edition of the tournament, the trophy will be contested by the traditional two teams – the reigning Scudetto and Coppa Italia holders.
Inter won the Supercoppa for two years running and are seeking a third, with almost a full squad at their disposal, missing only Juan Cuadrado and the not 100 per cent fit Alessandro Bastoni, who picked up a muscular problem in training yesterday.
Stefan de Vrij therefore steps in with Francesco Acerbi, while it is the usual pairing of Lautaro Martinez and Thuram upfront.
Napoli have Victor Osimhen and Andre Frank Zambo Anguissa on international duty at the Africa Cup of Nations, while Natan, Mathias Olivera and Alex Meret are injured.
A late change is that Mario Rui has a bruised foot, so Alessio Zerbin starts on the left flank, having scored twice against Fiorentina as a substitute.
Piotr Zielinski did not start the 3-0 win over Fiorentina due to a slight muscular issue and Walter Mazzarri sticks with his new 3-4-3 formation.
That means Simeone, Kvaratskhelia and Matteo Politano upfront, with Giacomo Raspadori on the bench.
When these teams met on December 3, Inter ran out 3-0 winners.
Napoli: Gollini; Di Lorenzo, Rrahmani, Juan Jesus; Mazzocchi, Cajuste, Lobotka, Zerbin; Politano, Simeone, Kvaratskhelia
Napoli bench: Contini, Idasiak, Demme, Mario Rui, Zielinski, Ngonge, Lindstrom, D’Avino, Ostigard, Gioielli, Gaetano, Raspadori
Inter: Sommer; Pavard, De Vrij, Acerbi; Darmian, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Lautaro Martinez
Inter bench: Di Gennaro, Audero, Dumfries, Sensi, Arnautovic, Klaassen, Frattesi, Buchanan, Asllani, Carlos Augusto, Bisseck, Stabile, Stankovic, Alexis Sanchez, Bastoni
Ref: Rapuano
VAR: Di Paolo