Milan give Christian Pulisic a new role with Rafael Leao, Samuel Chukwueze and Olivier Giroud against a Lecce side fresh from holding Roma.
It kicks off at San Siro at 14.00 UK time (13.00 GMT).
The Rossoneri have won four in a row to consolidate second place, but are forced into some changes.
Ruben Loftus-Cheek is suspended, with Malick Thiaw joining Pierre Kalulu and Tommaso Pobega on the injury list.
Theo Hernandez returns from his ban, but Pulisic is given a new role as a trequartista with Chukwueze, Rafael Leao and Giroud in a very attack-minded formation.
Lecce are coming off a win away to Salernitana and a 0-0 draw with Roma since coach Luca Gotti took over, so remain four points clear of the relegation zone.
Mohamed Kaba and Kastriot Dermaku are long-term absentees, but Lameck Banda is ready to start after recovering from a knee injury.
Milan: Maignan; Calabria, Gabbia, Tomori, Theo Hernandez; Adli, Reijnders; Chukwueze, Pulisic, Leao; Giroud
Lecce: Falcone; Venuti, Baschirotto, Pongracic, Gallo; Blin, Ramadani; Banda, Gonzalez, Dorgu; Krstovic
Player statistic
| Christian Pulisic (Assist: Samuel Chukwueze) |
 |
6' | ||
| Olivier Giroud (Assist: Yacine Adli) |
|
20' | ||
| 34' |  |
Alexis Blin | ||
| 45' |  |
Nikola Krstovic |
| Rafael Leão (Assist: Yacine Adli) |
|
57' | ||
| Samuel Chukwueze | |
78' |
Match statistic
