Romelu Lukaku is on the Napoli bench ready for his debut, but Khvicha Kvaratskhelia and Giacomo Raspadori start against giant-killers Parma.
It kicks off at the Stadio Diego Armando Maradona at 19.45 UK time (18.45 GMT).
Antonio Conte had a mixed start to his experience in Naples, needing penalties to scrape past Modena in the Coppa Italia and losing 3-0 at Verona in Serie A, but flattened Bologna 3-0 last week.
They also finally signed the players he was asking for, specifically Lukaku, Billy Gilmour and Scott McTominay, though only the Belgian is on the bench today.
Of course, there was also the drama surrounding Victor Osimhen, who is frozen out of the squad for the foreseeable future and Lukaku has been given his shirt number.
David Neres is also on the bench after providing an assist on his brief debut.
Fabio Pecchia’s Parma have made a big impact following promotion, holding Fiorentina and beating Milan 2-1.
Hernani, Yordan Osorio and Adrian Benedyczak are still out of action, but Ange-Yoan Bonny drops into a deeper role with Romania internationals Dennis Man and Valentin Mihaila, as 19-year-old Mateusz Kowalski starts upfront.
Napoli vs. Parma – where to watch on TV
The game is on Paramount+ in the USA. Fans in the UK and Ireland can watch it for free on OneFootball. beIN SPORTS 1 and streaming service beIN SPORTS CONNECT broadcast the Stadio Maradona clash live in Australia and New Zealand.
Napoli vs. Parma line-ups
Napoli: Meret; Di Lorenzo, Rrahmani, Buongiorno; Mazzocchi, Anguissa, Lobotka, Olivera; Politano, Kvaratskhelia; Raspadori
Parma: Suzuki; Coulibaly, Balogh, Circati, Valeri; Bernabè, Sohm; Man, Bonny, Mihaila; Kowalski
Player statistic
| 19' |  |
Ange-Yoan Bonny | ||
| Frank Anguissa |  |
43' |
| Stanislav Lobotka | |
58' | ||
| 61' | |
Valentin Mihăilă | ||
| 63' | |
Zion Suzuki | ||
| 75' |  |
Zion Suzuki | ||
| 88' | |
Enrico Del Prato | ||
| Romelu Lukaku (Assist: Leonardo Spinazzola) |
 |
90+2' | ||
| Frank Anguissa (Assist: David Neres) |
|
90+6' |
Match statistic
