Roma launch new signings Artem Dovbyk, Matias Soulé and Enzo Le Fée, but leave Paulo Dybala on the bench for the trip to Cagliari.
It kicks off at the Unipol Domus at 17.30 UK time (16.30 GMT).
The Giallorossi have been shaken over the last few days by news Dybala is in talks for a move to the Saudi Pro League, so while he is in the squad, he’s only on the bench.
Instead, Nicola Zalewski completes the trident attack with summer signings Soulé and Dovbyk, while Le Fée plays in midfield with Leandro Paredes suspended.
Cagliari won their competitive debut under new coach Davide Nicola, beating Carrarese 3-1 in the Coppa Italia.
Yerry Mina is suspended, with Nicolas Viola, Jakub Jankto, Jose Luis Palomino and Nadir Zortea not fully fit.
Cagliari vs. Roma line-ups
Cagliari: Scuffet; Zappa, Wieteska, Luperto; Azzi, Deiola, Prati, Marin, Augello; Luvumbo, Piccoli
Roma: Svilar; Celik, Mancini, N’Dicka, Angelino; Le Fee, Cristante, Pellegrini; Soulé, Dovbyk, Zalewski
Match statistic
