Lazio earned their second consecutive victory thanks to Pedro, Francesco Acerbi and Luis Alberto goals, as Venezia failed to make the most of their temporary equaliser.
Ciro Immobile was out after testing positive for COVID-19, with Elseid Hysaj injured, so Felipe Anderson was again used in a False 9 role. The Lagunari held Juventus and Sampdoria to 1-1 draws, with Thomas Henry ill, but had David Okereke and Ridgeciano Haps back in the squad.
It took just three minutes to break through with a pure solo effort, as Pedro started the run from midfield, rode a tackle and fired in from 14 yards.
Toma Basic blasted just over from distance, while Venezia had penalty appeals rejected for a potential handball.
The hosts equalised as Mattia Aramu whipped in a cross from the right for the glancing header of Francesco Forte, who had peeled away from his marker.
Lazio restored their advantage after the restart in curious circumstances, as the Danilo Cataldi in-swinging corner glanced off Francesco Acerbi’s shoulder and into the net.
Basic scuffed another promising opportunity, but Venezia fell apart in stoppages when American Tanner Tessmann saw red for a very clumsy challenge from behind on Luis Alberto.
Moments later, Luis Alberto spread the play down the right for Sergej Milinkovic-Savic, then fired in the return pass with a chest and volley from 10 yards. The Spaniard tried to celebrate by standing on the advertising board, but slipped and fell backwards.
Venezia 1-3 Lazio
Pedro 3 (L), Forte 30 (V), Acerbi 48 (L), Luis Alberto 95 (L)
Sent off: Tessmann 91 (V)