Andrea Sottil is tipped to field a largely unchanged side to the team that held newly crowned Serie A champions Napoli to a 1-1 draw at the Dacia Arena on Thursday evening.
Enzo Ebosse, Kingsley Ehizibue, Gerard Deulofeu, Simone Pafundi and Isaac Success all remain unavailable through various injuries.
Dejan Stankovic will be without Bruno Amione after his sending off during Wednesday night’s 2-0 loss to Torino, but Filip Djuricic is in line to make a return to action against Udinese. Koray Gunter is expected to start at centre-back in the absence of Amione.
Kick-off is at 17.30 UK time.
Udinese (3-5-1-1): Silvestri; Becao, Bijol, Perez; Ebosele, Samardzic, Walace, Lovric, Udogie; Pereyra; Nestorovski.
Sampdoria: (3-4-1-2): Ravaglia; Gunter, Nuytinick, Oikonomou; Zanoli, Winks, Rincon, Augello; Cuisance; Djuricic, Gabbiadini.
Empoli vs. Salernitana
Paolo Zanetti will be looking to make subtle alterations to his side after falling to a 4-1 loss against Bologna in the midweek round of Serie A fixtures.
Filippo Bandinelli is expected to start in midfield ahead of Alberto Grassi, who was given the nod last time out.
Salernitana Paulo Sousa will be unable to rely upon the suspended Domagoj Bradaric, as well as the injured Norbert Gyomber, Antonio Candreva, Domen Crnigoj, Federico Fazio and Diego Valencia.
Kick-off comes at 17.30 UK time.
Empoli (4-3-1-2): Vicario; Ebuehi, Walukiewicz, Luperto, Parisi; Akpa Akpro, Marin, Bandinelli; Baldanzi, Caputo, Cambiaghi.
Salernitana (3-4-2-1): Ochoa; Daniliuc, Lovato, Pirola; Sambia, Coulibaly, Vilhena, Mazzocchi; Kastanos, Maggiore; Dia.
Sassuolo vs. Bologna
Maxime Lopez becomes available to Alessio Dionisi after serving his suspension against Lazio last time out and is expected to return to the line-up in place of Pedro Obiang.
Thiago Motta will be unable to call upon Adama Soumaoro after picking up an injury to his right knee during Bologna’s 3-1 loss to Empoli on Thursday.
Elsewhere, Joshua Zirkzee is tipped to be given a start in the centre-forward role in place of Musa Barrow, whilst Marko Arnautovic could return to the matchday squad.
Kick-off arrives at 19.45 UK time.
Sassuolo (4-3-3): Consigli; Toljan, Erlic, Ferrari, Rogerio; Frattesi, Lopez, Henrique; Berardi, Defrel, Lauriente.
Bologna (4-2-3-1): Skorupski; Posch, Bonifazi, Lucumi, Cambiaso; Moro, Schouten; Orsolini, Ferguson, Dominguez; Zirkzee.