Juventus must cope without Federico Chiesa, but Massimiliano Allegri will start Moise Kean and Dusan Vlahovic against Spezia.
It kicks off at 17.00 GMT.
Interim coach Fabrizio Lorieri is in charge of Spezia after Luca Gotti was sacked earlier this week. The Aquilotti are expected to appoint Leonardo Semplici on Monday.
Salvatore Esposito is suspended. Jeroen Zoet, Emil Holm, Simone Bastoni, Joao Moutinho, and Szymon Zurkowski are injured. Mbala Nzola is back on the squad list but is not expected to start.
Gleison Bremer is suspended for Juventus, while Fabio Miretti, Federico Chiesa and Arek Milik are out of action. Leonardo Boncci returns.
Nicolò Fagioli is not fully fit, so he should start on the bench with Leandro Paredes, Adrien Rabiot and Manuel Locatelli in central midfield.
Angel Di Maria should rest ahead of next week’s Europa League clash with Nantes, so Kean and Vlahovic will start in attack. The Serbia international has scored five goals in as many appearances against Spezia but never in away games.
Spezia vs. Juventus: Probable line-ups
Spezia (3-5-2): Dragowski; Amian, Caldara, Nikolaou; Gyasi, Ampadu, Bourabia, Agudelo, Reca; Verde, Shomurodov.
Juventus (3-5-2): Perin; Danilo, Rugani, Alex Sandro; Cuadrado, Locatelli, Paredes, Rabiot, Kostic; Vlahovic, Kean.