Sassuolo head into the 27th round of Serie fixtures as one of the division’s form sides.
Only Napoli have picked up more points than Sassuolo over the last seven matches in Serie A.
However, the Neroverdi tend to be a little inconsistent, particularly off the back of big results. They have not won four in a row in the league since 2021.
Sassuolo will be without Brazilian centre-back Ruan through suspension after picking up his fifth yellow card of the season against Roma last Sunday.
Other than that, Alessio Dionisi will have a full squad of players to choose from with a clear injury list.
Spezia come into the game off the back of an impressive 2-1 win over Inter last Friday and will be hoping to record consecutive victories in Serie A for the first time since January 2022.
Spezia will have more of a limited set of options available to them, with Arkadiusz Reca, Emil Holm and Simone Bastoni still out injured.
The game kicks off at the Mapei at 17.30 GMT.
Sassuolo (4-3-3): Consigli; Toljan, Erlic, Ferrari, Rogerio; Frattesi, Lopez, Henrique; Berardi, Pinamonti, Laurienté.
Spezia (4-2-3-1): Dragowski; Amian, Caldara, Ampadu, Nikolau; Bourabia, Zurkowski; Gyasi, Agudelo, Shomurodov; Nzola.
Atalanta have struggled for goals in recent weeks, failing to find the net in any of their previous three outings in Serie A.
La Dea will be hoping to avoid going four games without a goal for the first time in Gian Piero Gasperini’s seven-year reign.
Gasperini will be without Berat Djimsiti, Hans Hateboer and Teun Koopmeiners for the visit of Empoli.
Empoli have lost three Serie A games on the bounce and will be hoping to avoid a fourth defeat in succession for the first time since 2018.
Guglielmo Vicario and Atalanta loanee Nicolo Cambiaghi will definitely miss out on the trip to Bergamo through injury.
Atalanta (3-4-1-2): Musso; Toloi, Scalvini, Palomino; Zappacosta, De Roon, Ederson, Maehle; Pasalic; Hojlund, Lookman.
Empoli (4-3-1-2): Perisan; Ebuehi, Ismajli, Luperto, Parisi; Akpa Akpro, Marin, Bandinelli; Baldanzi; Caputo, Satriano.