Sampdoria have Manolo Gabbiadini up front with Francesco Caputo, when Spezia arrive for the local derby with half the squad out.
The match kicks off at 19.45 UK time.
Roberto D’Aversa needs a positive result, but has to deal with many absences against the Aquilotti.
Morten Thorsby is suspended, while Mikkel Damsgaard and Albin Ekdal are out. Gabbiadini, however, is confirmed up front with former Sassuolo striker Caputo.
Thiago Motta arrive with double figures of injuries ahead of the derby, but Giulio Maggiore and Viktor Kovalenko are starting.
Line-ups: Sampdoria vs. Spezia
Sampdoria (4-4-2): Audero; Bereszynski, Yoshida, Colley, Augello; Candreva, Silva, Askildsen, Verre; Gabbiadini, Caputo
Spezia (4-2-3-1): Provedel; Ferrer, Nikolaou, Hristov; Bastoni; Maggiore, Kovalenko; Antiste, Salcedo, Gyasi; Strelec