The Blucerchiati were missing Stefano Sensi, Sebastian Giovinco, Manolo Gabbiadini, Mikkel Damsgaard, Kristoffer Askildsen and Maya Yoshida. Empoli were without Valerio Verre against his old club, Riccardo Marchizza, Sebastiano Luperto and Nicolas Haas.
Instead, Samp took the lead on an Antonio Candreva assist, as Quagliarella slipped, but still managed to steer the right-foot angled drive into the far bottom corner. This ended a 139-day goal drought for the veteran and means he has found the target for the 18th consecutive calendar year.
Sampdoria doubled their advantage with another Quagliarella goal, his 100th in the Blucerchiati jersey. Bartosz Bereszynski laid it off from the right, Quagliagol flicked it up with his first touch and fired in on the half-volley from 14 yards.
There was also bad news, because Bereszynski and Candreva were booked, so will be suspended next week against Atalanta.
Sampdoria 2-0 Empoli
Quagliarella 14, 29 (S)