Paulo Dybala returns to Roma‘s starting XI but may not play 90 minutes against Lazio who will rely on Ciro Immobile and Felipe Anderson.
The Rome derby kicks off at 17:00 UK time (GMT+1).
Lazio are unbeaten in the last four meetings with their city rivals and Roma’s last goal and victory against the Biancocelesti came in March 2022, over two years ago.
It’s the first Rome for Daniele De Rossi and Igor Tudor in their managerial career.
The Giallorossi are without the suspended Evan N’Dicka and the injured Sardar Azmoun.
Diego Llorente will start alongside Gianluca Mancini in central defence and Zaki Celik is favourite over Rick Karsdorp as a right-back.
Dybala will return to Roma’s starting XI, but De Rossi suggested on Friday that the Argentinean may not play 90 minutes. Roma will visit Milan in the Europa League quarter-final first leg on Thursday next week.
Ivan Provedel, Manuel Lazzari and Mattia Zaccagni are injured for Lazio, but Nicolò Rovella and Luca Pellegrini have recovered from injuries and are eligible to play.
Luis Alberto is expected to start on the bench, making room for Daichi Kamada and Gustav Isaksen behind Italy striker Immobile.
Roma vs. Lazio – probable line-ups
Roma (4-3-3): Svilar; Celik, Mancini, Llorente, Spinazzola; Cristante, Paredes, Pellegrini; Dybala, Lukaku, El Shaarawy.
Lazio (3-4-2-1): Mandas; Casale, Romagnoli, Gila; Marusic, Guendouzi, Vecino, Felipe Anderson; Isaksen, Kamada; Immobile.