They both kick off at 20.00 UK time (19.00 GMT).
Salernitana have a two-point advantage over Cagliari going into the final game of the season and their head-to-head record is identical after a pair of 1-1 draws.
The next dividing factor is overall goal difference, which has Cagliari in a far better position, so if they finish level on points, the Sardinians will stay up.
Genoa and Venezia are already doomed to the drop.
Salernitana: Belec; Gyomber, Radovanovic, Fazio; Mazzocchi, L Coulibaly, Bohinen, Ruggero; Verdi; Djuric, Bonazzoli
Udinese: Padelli; Becao, Nuytinck, N Perez; Molina, Pereyra, Walace, Makengo, Udogie; Deulofeu, Nestorovski
Venezia: Maenpaa; Svoboda, Caldara, Ceccaroni; Mateju, Crnigoj, Ampadu, Peretz, Haps; Cuisance, Johnsen
Cagliari: Cragno; Altare, Ceppitelli, Carboni; Bellanova, Nandez, Grassi, Deiola, Lykogiannis; Joao Pedro, Pavoletti